Kokomo Tribune; Kokomo, Indiana

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July 17, 2014

Studies see new risks for cholesterol drug niacin

Eds: Subs 8th paragraph to show that Niaspan now sold by AbbVie, which was spun off of Abbott, links photo..

New details from two studies reveal more side effects from niacin, a drug that hundreds of thousands of Americans take for cholesterol problems and general heart health. Some prominent doctors say the drug now seems too risky for routine use.

Niacin is a type of B vitamin long sold over the counter and in higher prescription doses. Some people take it alone or with statin medicines such as Lipitor for cholesterol problems.

Niacin users' main complaint has been flushing, so drug companies have been testing extended-release and combining other medicines with it to minimize that problem. Introduced in the 1950s, the drug hadn't been rigorously tested until recent years when makers of prescription versions were seeking market approval.

The two studies were testing prescription versions of niacin, and the bottom line — that it didn't help prevent heart problems any more than statins alone do — has already been announced. Some of the side effect information, including a troubling rise in deaths among niacin users in one study, also was known but many doctors have been waiting for full details and verification of the results before drawing firm conclusions about the drug's safety and effectiveness.

Those details are in this week's New England Journal of Medicine.

The larger study suggests that "for every 200 people that we treat with niacin, there is one excess death," plus higher rates of bleeding, infections and other problems — "a completely unacceptable level" of harm, said Dr. Donald Lloyd-Jones of Northwestern University in Chicago. "Niacin should not be used routinely in clinical practice at all."

He co-led a panel for the American Heart Association and American College of Cardiology that recently issued new cholesterol treatment guidelines. The group did not recommend niacin but said it could be considered for certain patients. If the panel had seen the new results, it "almost certainly" would have recommended against niacin's routine use, Lloyd-Jones said.

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