The large video screen then cut to a fan holding a sign that that read "Thanks Peyton But Tonight I'm A Colts Fan."
Afterward, he acknowledged it was an emotional game.
But the Broncos were dealing with far bigger issues on the field.
After Holliday fumbled, Luck hooked up with Darrius Heyward-Bey on the next play to give Indy a 10-7 lead.
Mathis' second-quarter strip sack forced a safety and Luck found Stanley Havili for a 20-yard TD pass after the free kick to make it 19-14. Indy never trailed again.
"That's my job, that's how I help my team," Mathis said. "It felt good."
The Colts extended the lead to 26-14 at halftime and 33-14 in the third quarter when Luck scrambled for a 10-yard TD during a drive on which four flags came out on Denver defenders.
Then Manning rallied the Broncos, throwing a 31-yard TD pass to Demaryius Thomas early in the fourth and handing off to Knowshon Moreno for a 1-yard TD run to make it 36-30 with 8:44 left in the game.
Denver forced a punt, giving Manning another chance as the stadium noise subsided. But on the first play, Erik Walden hit Manning's arm and Pat Angerer picked it off to set up Adam Vinatieri's 42-yard field goal.
"Hopefully we'll have a chance to play these guys again because that would mean we made the playoffs," Manning said. "I think if there is a next time it may be a little bit easier just because it was somewhat of an emotional week and it can be a little bit draining, I will say that."