Kiser added two final scores for the Panthers. He scored from 56 yards in the third quarter, and two yards in the fourth quarter.
Carroll (6-5) avoided the shutout as Jaden Reneau ran in from two yards with 4:46 left in the game.
Mersch led Pioneer with 204 yards rushing on 21 carries with two touchdowns. Kiser had 133 yards rushing on eight carries and three touchdowns.
Reneau led Carroll with 87 yards on 17 carries and a touchdown. Chandler Eurit added 82 yards on 12 carries.
Pioneer plays at Frontier for the sectional championship next Friday.